Designing DNA interstrand lock for locus-specific methylation detection in a nanopore
نویسندگان
چکیده
منابع مشابه
Designing DNA interstrand lock for locus-specific methylation detection in a nanopore
DNA methylation is an important epigenetic regulation of gene transcription. Locus-specific DNA methylation can be used as biomarkers in various diseases including cancer. Many methods have been developed for genome-wide methylation analysis, but molecular diagnotics needs simple tools to determine methylation states at individual CpG sites in a gene fragment. In this report, we utilized the na...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2013
ISSN: 2045-2322
DOI: 10.1038/srep02381